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KMID : 1013220070050010036
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Jouranl of the Korean Society of Clinical Toxicology
2007 Volume.5 No. 1 p.36 ~ p.42
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Epidemiology and Clinical Analysis of Poisoning of Glufosinate Herbicide -Multicenter Study-
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Lee Sung-Woo
Eo Eun-Kyung
Oh Bum-Jin
Lee Mi-Jin
Hong Yun-Sik
Park Joon-Seok
Kwon Woon-Yong
Seo Joo-Hyun
Roh Hyung-Keun
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Abstract
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Purpose: To assess the epidemiology and the clinical features of Glufosinate herbicide in Korea.
Methods: Data was prospectively collected during 1 year since August 2005 from 38 hospital in Korea. We analyzed the epidemiologic characters and clinical manifestations of Glufosinate poisoning. In addition, the characteristics of patients with severe central nervous system toxicity were separately analyzed to find poor prognosis relating factors.
Results: During study periods, there were 715 persons of poisoning of herbicides and insecticides. 6.3% (45 persons) of the agricultural chemicals poisoning had Glufosinate poisoning. There were 36 cases of suicide attempts and 7 cases of accidental exposure, The major of poisoning route was oral ingestion (44 cases). 28.9 % of the study patients had not toxic symptoms. The most common symptoms were gastrointestinal symptoms relating surfactant irritation. 67.7% of central nervous symptoms occurred lately. 10 persons showed severe central nervous system toxicity. 4 persons of them showed poor outcomes (1 death, 3 hopeless discharged). Complications of respiratory failure and renal failure related with poor outcome.
Conclusion: Majority of patients ingested Glufosinate for suicide attempt. 22.2% of patients with Glufosinate poisoning showed delayed serious central nervous system toxicity. Early supportive care of altered mentality may prevent late respiratory complications and improve the outcomes.
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KEYWORD
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Phosphinothricin, Glufosinate, Herbicides, Central nervous system, Toxicity
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